CasPlus PLATFORM
FOR GENE EDITING
The CasPlus platform pairs Cas nucleases with an engineered DNA repair enzyme to achieve high editing efficiency while minimizing unwanted genomic modifications. CasPlus can potentially work with different Cas nucleases to enable the correction of diverse mutations. CasPlus has wide applicability and superior editing efficiency compared to existing technologies with the ability to produce 1 -3 base pair insertions in a predictable and template-free approach. These attributes uniquely position CasPlus within the toolbox of gene editing technologies.
CasPlus DIAGRAM
The CasPlus platform pairs Cas nucleases with an engineered DNA repair enzyme to achieve high editing efficiency while minimizing unwanted genomic modifications.
CasPlus can potentially work with different Cas nucleases to enable the correction of diverse mutations.
CasPlus has wide applicability and superior editing efficiency compared to existing technologies with the ability to produce 1 -3 base pair insertions in a predictable and template-free approach. These attributes uniquely position CasPlus within the toolbox of gene editing technologies.
Videos
Visualizing the Future of Medicine
The Cas+ (Cas Plus) technology enhances traditional CRISPR-Cas systems by integrating a proprietary engineered DNA polymerase that enables controlled DNA repair and precise frame shifts. This modular and portable system minimizes collateral damage and chromosomal rearrangements, offering a safer and more versatile gene editing approach across diverse cell types.
CRISPR is a genome editing technology that uses a Cas enzyme guided by RNA to target and cut specific DNA sequences based on a nearby PAM site. While powerful, the method can lead to unintended DNA deletions and harmful chromosomal rearrangements, raising significant safety concerns.
